Predictive model should avoid need for surgery in rectal cancer

Predictive model should avoid need for surgery in rectal cancer

World Cancer Day, 4 February

Two research groups from the Vrije Universiteit Brussel have established a collaboration in which they predict the response to the standard treatment for rectal cancer based on medical images (e.g. CT scan) and clinical parameters (age, sex, tumour stage, etc.) – data that is available at the time of diagnosis. The aim is to use Random Subspace Decision Forest Analysis to avoid possible surgical interventions. To this end, the researchers, from the TROP Research Group (Translational Radiation, Oncology and Palliative Care) and the BISI Research Group (Biostatistics and Medical Informatics), led by VUB professor and head of the radiotherapy department of UZ Brussel Mark De Ridder and VUB professor Kurt Barbé, are developing a new and usable model.

Rectal cancer is located in the last 15 centimetres of the colon. About one-third of all colon cancers are rectum cancers. They, like other colon cancers, have a bad reputation, and even for those who recover, they often have drastic consequences. They are treated with radiotherapy, chemotherapy and, in many cases, surgery.

Surgery with sometimes serious consequences

“If surgery is required, the consequences are sometimes far-reaching,” says Inès Dufait, postdoctoral researcher at TROP. “During such operations, it is in fact sometimes difficult to spare the sphincter, with all the consequences that this entails. Unfortunately, the majority of patients who undergo surgery without the sphincter being removed are still confronted with several side effects, called low anterior resection syndrome (LARS), a drastic syndrome characterised by incontinence, difficulties in going to the toilet, frequent and high-pressure toilet visits, a lot of gas in the bowels and cramps that can last for more than 10 years. The lives of patients with this syndrome, as well as the lives of their partners and families, are dominated by their altered bowel functions which have a major impact on quality of life. Patients report that even a small improvement in their symptoms can mean a significant improvement in their quality of life. Currently, there are several ways to help combat these symptoms, such as an appropriate diet, pelvic strengthening exercises, nutritional supplements and certain medications. Unfortunately, these are only tools and they cannot fight the symptoms of LARS with equal efficiency in all patients. We should therefore avoid surgery as much as possible, which can prevent LARS.”

Genetic information from tumour tissue

The standard treatment of rectal cancer has undergone a significant evolution in recent years. With marked improvements in radiotherapeutic and surgical techniques, surgeons are able to perform operations in which the sphincter is preserved when the tumour is removed far enough from the anus. Implementation of that technique may avoid a permanent stoma in a specific group of patients. But the goal remains to avoid surgery as much as possible.

The new model, based on artificial intelligence, tries to predict which patients will respond well to treatment so that surgery is not necessary. Currently, the model makes the correct prediction in 75 to 80% of cases. It was developed based on the data of patients who have already been treated and is now in the testing phase. Patients whose chances have been estimated by the model are closely followed up so that adjustments can be made in time.

The next step is now to evaluate the model in clinical practice and to apply it to patients with locally advanced rectal cancer who are still at the beginning of their treatment path. In the near future, researchers will also work hard to improve the model even further, by using genetic information obtained from the tumour tissue itself. To realise the project, an application was submitted to the cancer charity Kom op tegen Kanker, the result of which will be announced shortly.

Quotes:

“When rectal cancer requires surgical intervention, the consequences are sometimes far-reaching”

“Artificial intelligence can correctly predict in 75 to 80% of cases how the patient will respond to treatment”

 

More information

Prof Mark De Ridder, Head of Department of Radiotherapy, UZ Brussel

[email protected]

+32 2 477 61 47

 

Prof Kurt Barbé, Biostatistics and Medical Informatics, Vrije Universiteit Brussel

[email protected]e

+32 2 477 47 27

 

Dr Inès Dufait, Department of Radiotherapy UZ Brussel

[email protected]

+32 2 477 45 34

 

VUB and cancer research

VUB is an Urban Engaged University that is firmly committed to the fight against cancer through scientific research. Scientists from various fields – medicine, bioengineering, pharmacy, physiotherapy, psychology – work together on an interdisciplinary basis. Fundamental and clinical scientific research into cancer go hand in hand, which is why the UZ Brussel, VUB’s university hospital, is an important partner in research, therapy and care. More awareness about cancer is needed for its prevention and cure, while more awareness about scientific research benefits the search for remedies and patient well-being. VUB is therefore grateful for an initiative such as World Cancer Day on 4 February.

The VUB Foundation helps to secure financial resources for research. With the VUB Yamina Krossa Fund, the VUB Foundation supports breast cancer research and the development of a potential cancer vaccine by Professor Damya Laoui and her team (VUB-VIB). The VUB-UZB Paul De Knop Fund is another initiative, established by the former VUB rector who was diagnosed with melanoma shortly after his mandate ended. During treatment by Prof Bart Neyns and his team at the UZ Brussel, Paul De Knop underwent immunotherapy, a promising immune system-based cell therapy. As a grateful patient, he set up the fund to help more people in need of treatment, quickly and more affordably.

Want to know more? Contact Isabelle Marneffe ([email protected]), director of the VUB Foundation. www.vubfoundation.be

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Sicco Wittermans
Sicco Wittermans Woordvoerder en persrelaties Vrije Universiteit Brussel
Karolien De Prez
Karolien De Prez Spokesperson, UZ Brussel
Sicco Wittermans
Sicco Wittermans Woordvoerder en persrelaties Vrije Universiteit Brussel
Karolien De Prez
Karolien De Prez Spokesperson, UZ Brussel
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